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KMID : 1035620150030050375
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Allergy Asthma & Respiratory Disease
2015 Volume.3 No. 5 p.375 ~ p.379
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Iodinated contrast media-induced fixed drug eruption
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심지수:Shim Ji-Su
정수지:Chung Soo-jie/김건우:Kim Gun-Woo/손경희:Sohn Kyoung-Hee/김주영:Kim Ju-Young/강혜련:Kang Hye-Ryun
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Abstract
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Iodinated contrast media (ICM) can cause not only immediate onset hypersensitivity but also delayed onset hypersensitivity. While the most common form of delayed onset hypersensitivity reaction to ICM is exanthematous eruption, fixed drug eruption (FDE) can occur rarely related to ICM. A 70-year-old male with liver cirrhosis and hepatocellular carcinoma repeatedly experienced erythematous patches on his right forearm and hand 6 hours after exposure to iopromide for computed tomography scan. ICM induced FDE was diagnosed clinically. Intradermal test with 6 kinds of ICM (iobitridol, iohexol, iomeprol, iopamidol, iopromide, and iodixanol) was performed and showed the weakest positive reaction to iohexol compared to the others in 48 hours. After changing iopromide to iohexol based on these results, FDE did not recur. We report here a case of iopromide induced FDE which was successfully prevented by changing ICM to iohexol based on intradermal test results.
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KEYWORD
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Contrast media, Drug eruptions, Delayed hypersensitivity, Intradermal tests
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